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- W2390465452 abstract "Objective: To evaluate the efficacy and feasibility of gamma knife FSRT (fractionated stereotactic radiotherapy) with super gamma knife for BM (brain metastasis) and investigate the related prognostic factors. Methods: The complete clinical records were colleceted and retrospectively analyzed from 120 BM patients (including 71 males and 49 females) receiving gamma knife FSRT between March 2007 and November 2011. The median age was 49 (range: 34-84) years old. The median dose of FSRT was 35 (range: 28-45) Gy in 7 (range: 4-10) fractions. Median planning target volume was 3.95 (0.14-25.56) cm3. The patients were followed-up and the follow-up rate was 97.5% [median follow-up time was 12 months (range: 1-50 months)]. The Kaplan-Meier method, log-rank test and COX regression model were used for survival and prognostic analysis. Results: Of 120 patients, 63 (52.50%) achieved complete response, 47 (39.17%) achieved partial response, 8 (6.67%) achieved stable disease, and 2 (1.67%) achieved progressive disease. The overall response rate was 98.33% (118/120), and the six-month overall tumor control rate was 96.58% (113/117). The median survival time was 11 months (range: 3-50 months; 95% confidence interval: 7.8-15.6). The 1-, 2- and 3-year overall survival rates were 44.17%, 23.60% and 9.84%, respectively. The multivariate analysis showed that RPA (recursive partitioning analysis) class and extracranial lesion status were independent prognostic factors (P < 0.05). Conclusion: The patients with BM have a good response to Gamma knife FSRT, and the side effects are tolerable. RPA class and extracranial lesion status are independent prognostic factors for BM patinets receiving gamma knife FSRT. DOI:10.3781/j.issn.1000-7431.2013.08.011" @default.
- W2390465452 created "2016-06-24" @default.
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- W2390465452 date "2013-08-25" @default.
- W2390465452 modified "2023-09-26" @default.
- W2390465452 title "Clinical outcomes of fractionated stereotactic radiotherapy for brain metastasis with gamma knife and prognostic analysis" @default.
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