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- W2390468105 abstract "Objective To investigate the antitumor bioactive ingredient of a endophytic fungus Penicillium sp.LD-68 isolated from Guang Xi mangrove plant Hibiscus tiliaceus L..Methods The extract of the fungus was purified by solvent extraction,column chromatography and preparative HPLC guided by the bioassay results.Their structures were established by physicochemical properties and spectroscopic analysis.The antitumor activities were evaluated by SRB method and MTT method.Results Five compounds were identified as curvularin(1),dehydrocurvularin(2),11-β-Hydroxy-12-Oxocurvularin(3),11-β-Hydroxycurvularin(4),11-α-Hydroxycurvularin(5).Compounds 1～5 showed inhibitory activities to four kinds of human tumor cell lines including A549,hela,BEL-7402 and K562,and compounds 2～5 have more potential antitumor activities against hela cells,with IC50 values of 3.99,7.75,10.00 and 5.10μM,respectively.Conclusion Compounds 3～5 are reported their cytoxic activities against the four kinds of human tumor cell lines,A549,hela,BEL-7402 and K562 for the first time,and exhibiting more selectivities to hela cell line." @default.
- W2390468105 created "2016-06-24" @default.
- W2390468105 creator A5057007703 @default.
- W2390468105 date "2012-01-01" @default.
- W2390468105 modified "2023-09-24" @default.
- W2390468105 title "Secondary metabolites and their bioactivities of Hibiscus tiliaceus L. endophytic fungi" @default.
- W2390468105 hasPublicationYear "2012" @default.
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