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- W2390470983 abstract "Objective To study immunomodulatory effects of Paeonol extract on systemic lupus erythematosus(SLE) mice and their associated mechanisms preliminary inquiry.Methods BALB / C mice were given parental mixed lymphocyte suspension by intravenous injection to establish the SLE model.The mice with urinary protein concentration range in0.1-1.0 g·L-1were selected.Then mice were randomly divided into five groups according to body weight and urine protein concentrations,control group,model group,prednisone acetate group(5.0 × 10-3g·kg-1),high and low doses(2.0,1.0 g·kg-1) of Paeonol water extract groups.Each group received corresponding drugs for 10 weeks.The blood from retinal vein plexus was taken.Then the animals were sacrificed.The ratio of CD4 + CD25 + Fox P 3 + regulatory T cells(Treg)cells and interleukin 17(Th17) cells in peripheral blood were detected by flow cytometry.The content of interferon-γ(IFN-γ) and IL-17 in plasma was tested by enzyme-linked immunosorbent assay.The expression of Fox P3 was detected by Western blot.Results Compared withmodel group,the ratio of CD4 + CD25 + Fox P3 + Treg cells of plasma in Paeonol water extract groups were increased after administration for 10 weeks.The mean fluorescence intensity and the expression of Fox P3 were significantly enhanced(P 0.05).The ratio of Th17 / CD4+was lower(P 0.05).The IL-17 and IFN-γ content in plasma were reduced(P 0.05).Conclusion Paeonol water extract play a protective role by increasing Treg and inhibiting the ratio of helper T cells Th17 in mouse model of SLE." @default.
- W2390470983 created "2016-06-24" @default.
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- W2390470983 date "2015-01-01" @default.
- W2390470983 modified "2023-09-25" @default.
- W2390470983 title "Study on immunomodulatory effects and mechanism of Paeonol extract in mice with systemic lupus erythematosus" @default.
- W2390470983 hasPublicationYear "2015" @default.
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