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- W2390496585 abstract "A variety of chronic liver diseases are associated with sterile inflammation of the tissues. Some nucleotide-binding oligomerization domain-like receptors form the inflammasome, a cytosolic multiprotein complex, which is an important component of sterile inflammation. It can be activated by a large amount of exogenous or endogenous signals, thus inducing the secretion of inflammatory cytokines and tissue inflammation, and excessive stimulation can cause tissue damage. Research studies have shown that the inflammasome plays a critical role in many chronic liver diseases, such as alcoholic or non-alcoholic fatty liver disease, is-chemia-reperfusion injury of liver and drug-induced liver injury. Inflammasome is an important determinant of liver fibrogenesis and carcinogenesis. This reviewe focuses on the structure of inflammasome, the related activation signal and pathway, regulatory mechanism and its association with chronic liver diseases. Further identification of its role may shed light on new approaches for the treatment of chronic liver diseases." @default.
- W2390496585 created "2016-06-24" @default.
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- W2390496585 date "2013-01-01" @default.
- W2390496585 modified "2023-09-28" @default.
- W2390496585 title "Inflammsomes in chronic liver diseases" @default.
- W2390496585 hasPublicationYear "2013" @default.
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