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- W2390499097 abstract "Objective To explore the expression of nuclear factor-κB(NF-κB)and the mechanism on the treatment of epilepsy with acupuncture at the Governor Vessel points.Methods Litium chloride-pilocarpine was used to establish the epilepsy model in rats.The immunohistochemical method(IHC)was adopted to observe the expression of hippocampal NF-κB in rats.Results The NF-κB immune reactive positive cells were more distributed in the cellular plasma and less in the nucleus of the rats in the blank group.The NF-κB immune reactive positive cells were more distributed in the nucleus in the epilepsy rats of the model group.The difference in the expression of NF-κB was significant statistically between the epilepsy rats in the model group and those in the blank group(P0.05).The difference in the expression of hippocampal NF-κB was significant statistically between the acupuncture group and the epilepsy rats in the model group(P0.05).Conclusion After activated in a seizure,NF-κB is transferred to the nucleus and its expression is increased apparently.Acupuncture at the Governor Vessel points inhibits obviously the hippocampal NF-κB expression in the rats of epilepsy.In mechanism,the impulse afferent central nerve is stimulated,NF-κB expression is inhibited appropriately,the mediated inflammatory reaction is alleviated,the excessive apoptosis is restricted and the neuron excitability is reduced.As a result,epilepsy is inhibited." @default.
- W2390499097 created "2016-06-24" @default.
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- W2390499097 date "2013-01-01" @default.
- W2390499097 modified "2023-09-23" @default.
- W2390499097 title "Impacts of Acupuncture at the Governor Vessel Points on the Expression of Hippocampal NF-κB in the Rats of Epilepsy" @default.
- W2390499097 hasPublicationYear "2013" @default.
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