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- W2390528261 abstract "Objective To determine the relationship between GSTM1 and GSTT1 genetic polymorphisms and here-ditary susceptibility to age-related hearing loss. Methods Specimens in this study were selected from the database at the Deafness Molecular Diagnosis Center, Institute of Otorhinolaryngology, Chinese PLA General Hospital for genomic DNA extraction. The genetic polymorphisms of GSTM1 and GSTT1 were detected by multiplex polymerase chain reaction. The results were compared to the control and χ2 test was used to determine the frequency and association of genotype of GSTM1 and GSTT1. Results This study included 224 specimens, including those from cases of age-related hearing loss (n=110, PTA=51±11 dB HL) and from age-matched controls(n=114, PTA=18±4 dB HL) All subjects were between 60° to 80 years of age. The average age of the age related hearing loss group(77 males and 33 females) was 72.93 ± 5.08 years, and that of the control group (76 males and 38 females) was 73.10 ± 5.787 years. Genotyping and statistical analysis revealed no difference between patients with age related hearing loss and the controls regarding GSTM1, GSTT1 genotype positive rate and frequencies of GSTT1+/GSTM1+, GSTT1+/GSTM1-, GSTT1-/GSTT1+ and GSTT1-/GSTM1- genotypes (P 0.05). Conclusion We are unable to detect a strong association between GSTM1、 GSTT1 gene and age related hearing loss in this Chinese population." @default.
- W2390528261 created "2016-06-24" @default.
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- W2390528261 date "2011-01-01" @default.
- W2390528261 modified "2023-09-25" @default.
- W2390528261 title "Association analysis of GSTT1 and GSTM1 genes with hereditary susceptibility to age-related hearing loss among Chinese" @default.
- W2390528261 hasPublicationYear "2011" @default.
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