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- W2390528810 abstract "Objective:To study the neuroprotective effect of emodin-3-methyl ether on hypoxic-induced PC12 cell injury.Methods: The hypoxic injury model of nerve cell was established in cultivated PC12 cells.The cells were pretreated with emodin-3-methyl ether before establishment of cell model.The cellular proliferation was detected with MTT assay,the cellular morphology was observed under light microscope,the supernatant lactate dehydrogenase(LDH) concentration was determined,the c-fos protein expression was measured with fluorescent immunohistochemistry,and the expressions of nNOS and iNOS mRNA were identified by RT-PCR assay.Results:The cellular morphologic study showed that the emodin-3-methyl ether could obviously increase the anti-hypoxia activity of PC12 cells.After pretreatment with emodin-3-methyl ether,the cellular survival rate was significantly increased,the supernatant LDH level was obviously decreased,and the c-fos protein expression was markedly reduced(P0.05).The RT-PCR assay showed that the nNOS mRNA was mainly expressed in early stage and the iNOS mRNA expressed in late stage.Conclusion: The emodin-3-methyl ether could relieve the nerve cell injury induced by hypoxia,indicating that it may have neuroprotective effect on hypoxic injury of nerve cells." @default.
- W2390528810 created "2016-06-24" @default.
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- W2390528810 date "2012-01-01" @default.
- W2390528810 modified "2023-09-28" @default.
- W2390528810 title "Protective effect of emodin-3-methyl ether on hypoxic-induced nerve cell injury in PC12 cells" @default.
- W2390528810 hasPublicationYear "2012" @default.
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