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- W2390570100 abstract "Objective To investigate the effects of taurine on the disorder of energy metabolism and oxidative damage due to focal cerebral ischemia in rats.Methods Male Sprague-Dawley rats were subjected to 2h middle cerebral artery occlusion,and 22h reperfusion.Taurine(50g/kg,iv) was administrated intravenously 1h after ischemia.The contents of ATP,lactate and malondiadehyde(MDA),the activities of myeloperoxidase(MPO) and superoxide dismutase(SOD),and the total anti-oxidative ability in ischemic tissue were measured.Results Taurine markedly reduced the contents of lactate and MDA,and the MPO activity,and enhanced the SOD activity and the total anti-oxidative ability in ischemic tissue at 22h after reperfusion.Conclusion Postischemic treatment with taurine protects brain against focal cerebral ischemia through improving energy metabolism,enhancing the anti-oxidative ability,reducing the infiltration of neutrophils,and attenuating oxidative damage in rats." @default.
- W2390570100 created "2016-06-24" @default.
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- W2390570100 date "2008-01-01" @default.
- W2390570100 modified "2023-09-23" @default.
- W2390570100 title "Taurine reduces the disorder of energy metabolism and oxidative damage due to focal cerebral ischemia in rats" @default.
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