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- W2390579940 abstract "Objective To investigate the serum levels of IgM and low affinity IgG antibodies against Mycoplasma Pneumoniae (MP) in children with respiratory tract infection,and explore the value of the detection in early diagnosis of children’s MP infection.Methods Serum levels of MP-IgM antibody in children with respiratory tract infection were measured by using three methods:pellet agglutination assay (PGA),ELISA and indirect immuno-fluorescence(IIF) technique. Meanwhile, low affinity MP-IgG antibody was also detected by IIF.The serum levels of MP-IgM and low affinity MP-IgG antibodies were parallelly investigated.Results Serum levels of MP-IgM antibody were different due to discrepancy of test methods. 60.0% (51/88) of cases was positive by ELISA, 50.0% (44/88) of cases was positive by PGA, and 40.9% (36/88) of cases was positive by IIF. The result had significant association and moderate coincidence between PGA and ELISA (0.7Kappa0.4, P0.001), whereas the results between PGA and IIF, ELISA and IIF were inconsistent. 21 of all infective cases were higher levels of low affinity MP-IgG antibody (23.9% of positive cases), among whom 17 of 21 cases were synchronously accompanied by positive MP-IgM antibody, and both also had significant association and moderate coincidence (0.7Kappa0.4, P0.001).Conclusion Low affinity MP-IgG serves as a serum parameter of MP infection, provided with early diagnosis value analogous to MP-IgM antibody. So, the results of the assay were significantly important for distinguishing MP early infection, relapse after infection and second infection." @default.
- W2390579940 created "2016-06-24" @default.
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- W2390579940 date "2007-01-01" @default.
- W2390579940 modified "2023-09-26" @default.
- W2390579940 title "Detection of serum IgM and low affinity IgG antibodies against Mycoplasma Pneumoniae in children with respiratory tract infection" @default.
- W2390579940 hasPublicationYear "2007" @default.
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