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- W2390590160 abstract "Objective To establish 2 animal models in disorder of cortical development (DCDs) in Wistar rats. Methods Two animal models of DCDs are produced by γ-radiated pregnant rats and neonatal freeze lesion model. The litter of rats were divided into model groups and normal control groups. Before EEG recordings, daily activities of rats were observed. Rats were induced seizures by warm-water-immersion (45℃). The memory capacity was tested by using a Morris-water-maze method. Neuronal changes in hippocampus and cerebral cortex were detected by Nissl stain. Results (1) Model rat showed a thin cortical plate and distinct clusters of neuronal elements that represent heterotopias. In the control rat cortex, the typical six-layered lamination pattern was apparent, whereas the model rat cortex showed laminar disorganization and thinning. In addition, there were clusters of large neurons in both superficial and deep layers in the model rat cortex. (2) Animal model groups had less activities than the normal control group. (3) The latent period that warm-water-immerse induced the seizures ((3.47±0.48) minutes and (3.65±0.44) minutes respectively) was significantly shorter than the control ((4.66±0.58) minutes, P0.05). (4) The searching platform latency of the model rats was significantly longer than that of the normal controls (P0.05). Conclusion Animal models of DCDs established by radiated and freeze lesion should have decreasing seizure threshold and increased seizure susceptibility as well as cognitive handicap." @default.
- W2390590160 created "2016-06-24" @default.
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- W2390590160 date "2005-01-01" @default.
- W2390590160 modified "2023-09-26" @default.
- W2390590160 title "Study on animal models in disorders of cortical development of γ-radiated pregnant rats and freeze lesion neonatal rats" @default.
- W2390590160 hasPublicationYear "2005" @default.
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