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- W2390596571 abstract "Objective To assess consistency of the clinical and histopathological diagnosis,and investigate the association of HBV DNA with pathological degree in patients with YMDD mutations of hepatitis B virus(HBV).Methods 42 cases of YMDD mutations of chronic hepatitis B reviewed the content detection of HBV DNA and liver biopsy.The clinical diagnosis with pathological diagnosis was compared.The date about them were analyzed by Kappa test.37 cases with negative YMDD mutations which did not take lamuvidine were control group.We compared pathological degree with hepatic B virus copies between the positive YMDD mutations group and the control group.Results Kappa value=0.346(P0.01).The general coincidence of clinical and histopathological diagnosis for patients with YMDD mutations is 66.7%.The coincidence of mild,medium,severe hepatitis B were 83.3%,40.0%,66.7% respectively.Comparing with the control group,intrahepatic inflammatory histopathological grading in positive YMDD mutations group was mild,few of which were pathologically diagnosed as medium and severe hepatitis B.Conclusion The weak consistency is observed between the clinical and histopathological diagnosis for patients with YMDD mutations of HBV.So,it is necessary to perform the liver biopsy for patients without contraindication to establish diagnosis and evalue prognosis.Especially,patients with medium or severe hepatitis B in YMDD mutations should perform liver biopsy.It is important and effective for antiviral therapy of chronic hepatitis B." @default.
- W2390596571 created "2016-06-24" @default.
- W2390596571 creator A5086314842 @default.
- W2390596571 date "2007-01-01" @default.
- W2390596571 modified "2023-09-23" @default.
- W2390596571 title "Analysis of Clinical and Histopathological Diagnosis in YMDD Mutations of HBV" @default.
- W2390596571 hasPublicationYear "2007" @default.
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