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- W2390597801 abstract "Objective To investigate the relationship between the role of signal transducers and activators of transcription factor 3(Stat 3) signal transduction pathway and the mechanism of selective cyclooxygenase 2(COX 2) inhibitor,NS 398 against human colon cancer cell line HT 29. Methods HT 29 cells were treated with NS 398. MTT assay and flow cytometry were used to measure the cell proliferation and apoptosis. RT PCR and ELISA were used to detect the COX 2 mRNA expression level and PGE2 concentration of HT 29 cells,before and after treatment respectively. The expression of p Stat 3,p JAK2,cyclin D1 and Bcl 2 proteins was examined by Western blot. Results The high expression of COX 2 mRNA was detected in HT 29 cells. After treated by NS 398,an obvious decline in expression of COX 2 mRNA and PGE2 were found,along with the cells proliferation inhibiton and apoptosis induction in a dosage ,time dependent manner. A significant downregulation of p Stat 3,p JAK2,cyclin D1 and Bcl 2 expression was found with the treatment time. Conclusions Stat 3 signaling pathway may mediate the proliferative inhibition and apoptotic induction of HT 29 cells through the downregulation of cyclin D1,Bcl 2 expression." @default.
- W2390597801 created "2016-06-24" @default.
- W2390597801 creator A5040873485 @default.
- W2390597801 date "2004-01-01" @default.
- W2390597801 modified "2023-09-25" @default.
- W2390597801 title "The role of signal transducers and activators of transcription factor 3 signaling pathway in mechanism of selective cyclooxygenase-2 inhibitor against colon carcinoma cells" @default.
- W2390597801 hasPublicationYear "2004" @default.
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