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- W2390613260 abstract "Objective To study the clinical significance of serum interleukin-6 (IL-6), IL-10 and IL-12 levels in patients with hepatitis B. Methods The levels of serum hepatitis B virus (HBV) DNA were detected by Fluorescence quantitation polymerase chain reaction, IL-6, IL-10 and IL-12 by enzyme linked immunosorbent assay (ELISA) and serum alanine aminotransferase (ALT) were also detected in 100 hepatitis B virus patients and 100 healthy donors. Results The levels of IL-6, IL-10 and IL-12 in HBV infected patients were significantly higher than those in healthy donors (P0.01). Significant positive correlation was found between the levels of IL-6, IL-12 and the levels of ALT, respectively, but negative correlation was found between IL-10 and ALT. The positive correlation were also found between the levels of IL-6, IL-12 and the quantity of HBV DNA in the patients who had complete response to the treatments, but negative correlation was found between the levels of IL-10 and the quantity of HBV DNA. Simultaneously, the levels of IL-6, IL-10 and IL-12 in the responder patients were significantly higher than those in the non-responder patients (P0.01). Conclusions Serum levels of IL-6, IL-10 and IL-12 in hepatitis B virus patients reflect the immune function and injury degree of livers and may play an important role in forecasting the therapeutic effects and prognosis of hepatitis B virus patients." @default.
- W2390613260 created "2016-06-24" @default.
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- W2390613260 date "2007-01-01" @default.
- W2390613260 modified "2023-09-24" @default.
- W2390613260 title "Clinical significance of detection of serum cytokines levels in patients with hepatitis B" @default.
- W2390613260 hasPublicationYear "2007" @default.
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