Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390622275> ?p ?o ?g. }
- W2390622275 endingPage "531" @default.
- W2390622275 startingPage "d525" @default.
- W2390622275 abstract "Mycobacterium avium complex (MAC) group of microorganisms are the most common opportunistic bacterial pathogens causing disseminated disease in HIV infected patients. These microorganisms are ubiquitous in nature, and are acquired by respiratory and oral routes. Pathogenesis of MAC depends on the ability of the organisms to colonize intestinal/respiratory mucosa, penetrate the protective barriers and resist intracellular killing by macrophages. Transient and reversible variation of colony morphology is one the characteristic feature of MAC that plays a significant role in the virulence and pathogenesis of these microorganisms. Isogenic colony variants of MAC differ in their virulence, susceptibility to antibiotics, stimulation of oxygen radicals and cytokines. The virulent smooth transparent colony variants are more frequently isolated from AIDS patients, more efficient in mucosal colonization, and adhere more efficiently to epithelial cells as compared to the less virulent smooth opaque variants. However, both the isogenic variants bind to the mucosal epithelial cells through the same multiple receptors. In addition, both the isogenic variants of MAC also bind to intestinal mucus through a single receptor. Study of the interaction of MAC with the host cells and characterization of MAC adhesins and host cell receptors facilitates the elucidation of the mechanisms involved in MAC pathogenesis." @default.
- W2390622275 created "2016-06-24" @default.
- W2390622275 creator A5067562148 @default.
- W2390622275 date "1998-01-01" @default.
- W2390622275 modified "2023-09-24" @default.
- W2390622275 title "Mechanism of mycobacterium avium complex pathogenesis" @default.
- W2390622275 cites W1481219844 @default.
- W2390622275 cites W1529380952 @default.
- W2390622275 cites W1543251537 @default.
- W2390622275 cites W1587195158 @default.
- W2390622275 cites W1592780563 @default.
- W2390622275 cites W1592955279 @default.
- W2390622275 cites W1594638761 @default.
- W2390622275 cites W1600281413 @default.
- W2390622275 cites W1823466978 @default.
- W2390622275 cites W1839186707 @default.
- W2390622275 cites W1841196254 @default.
- W2390622275 cites W1861529024 @default.
- W2390622275 cites W1863042851 @default.
- W2390622275 cites W1866842658 @default.
- W2390622275 cites W1901653339 @default.
- W2390622275 cites W1923199377 @default.
- W2390622275 cites W1954999670 @default.
- W2390622275 cites W1970964835 @default.
- W2390622275 cites W1972614986 @default.
- W2390622275 cites W1977817937 @default.
- W2390622275 cites W1980020862 @default.
- W2390622275 cites W1993412905 @default.
- W2390622275 cites W1994868284 @default.
- W2390622275 cites W2009990134 @default.
- W2390622275 cites W2018228075 @default.
- W2390622275 cites W2028861996 @default.
- W2390622275 cites W2031759243 @default.
- W2390622275 cites W2033811563 @default.
- W2390622275 cites W2034629723 @default.
- W2390622275 cites W2034667569 @default.
- W2390622275 cites W2034983414 @default.
- W2390622275 cites W2042140498 @default.
- W2390622275 cites W2053780827 @default.
- W2390622275 cites W2062414564 @default.
- W2390622275 cites W2075834345 @default.
- W2390622275 cites W2095730944 @default.
- W2390622275 cites W2110317022 @default.
- W2390622275 cites W2122234647 @default.
- W2390622275 cites W2129465442 @default.
- W2390622275 cites W2130806171 @default.
- W2390622275 cites W2134767948 @default.
- W2390622275 cites W2136888669 @default.
- W2390622275 cites W2141475535 @default.
- W2390622275 cites W2147466355 @default.
- W2390622275 cites W2152884319 @default.
- W2390622275 cites W2157922622 @default.
- W2390622275 cites W2168209103 @default.
- W2390622275 cites W2185840583 @default.
- W2390622275 cites W2187116198 @default.
- W2390622275 cites W2192032207 @default.
- W2390622275 cites W2222034304 @default.
- W2390622275 cites W2314203359 @default.
- W2390622275 cites W2316613526 @default.
- W2390622275 cites W2327117766 @default.
- W2390622275 cites W2341862408 @default.
- W2390622275 cites W2342728331 @default.
- W2390622275 cites W2408133941 @default.
- W2390622275 cites W330383352 @default.
- W2390622275 cites W603314494 @default.
- W2390622275 cites W886535560 @default.
- W2390622275 cites W3112434901 @default.
- W2390622275 doi "https://doi.org/10.2741/a300" @default.
- W2390622275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9616131" @default.
- W2390622275 hasPublicationYear "1998" @default.
- W2390622275 type Work @default.
- W2390622275 sameAs 2390622275 @default.
- W2390622275 citedByCount "18" @default.
- W2390622275 countsByYear W23906222752012 @default.
- W2390622275 countsByYear W23906222752013 @default.
- W2390622275 countsByYear W23906222752015 @default.
- W2390622275 countsByYear W23906222752016 @default.
- W2390622275 countsByYear W23906222752017 @default.
- W2390622275 countsByYear W23906222752019 @default.
- W2390622275 countsByYear W23906222752021 @default.
- W2390622275 crossrefType "journal-article" @default.
- W2390622275 hasAuthorship W2390622275A5067562148 @default.
- W2390622275 hasConcept C104317684 @default.
- W2390622275 hasConcept C170493617 @default.
- W2390622275 hasConcept C179470777 @default.
- W2390622275 hasConcept C18903297 @default.
- W2390622275 hasConcept C203014093 @default.
- W2390622275 hasConcept C2777312293 @default.
- W2390622275 hasConcept C2780374374 @default.
- W2390622275 hasConcept C2780942790 @default.
- W2390622275 hasConcept C523546767 @default.
- W2390622275 hasConcept C54355233 @default.
- W2390622275 hasConcept C60987743 @default.
- W2390622275 hasConcept C86803240 @default.
- W2390622275 hasConcept C89423630 @default.
- W2390622275 hasConceptScore W2390622275C104317684 @default.
- W2390622275 hasConceptScore W2390622275C170493617 @default.
- W2390622275 hasConceptScore W2390622275C179470777 @default.