Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390652007> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2390652007 endingPage "5" @default.
- W2390652007 startingPage "621" @default.
- W2390652007 abstract "To study the control effects of HIM82 and HIM70 on reactive oxygen species (ROS) released from respiratory burst of neutrophils (Np), and the action of HIM82 on relevant signal transduction pathway.The experimental group (combining with McAb) was compared with the control group with regard to the ROS level, activity of G protein, intracellular [Ca2+] level, the activities of PKC and PTK in activated Np to interpret the mechanism by which the McAb down-regulated the respiratory burst.The positive rate of Np combined with HIM82 was shown over 95% using indirect immunofluorescence assay (control group was 0). The generation of superoxide anion and hydrogen peroxide from PMA-treated Np were decreased by 55% (P < 0.01) and 32% (P < 0.01) with 30 micrograms/ml HIM82. The amount of H2O2 produced in FMLP or SP-stimulated Np were decreased by 16% (P < 0.01) and 37% (P < 0.01) respectively. A similar effect of HIM70 on Np was observed. Furthermore, the inhibition of H2O2 in FMLP-activated Np affected by PT, a specific inhibitor for G-protein, and in HIM82 was 42% and 60% separately, and that with both PT and HIM82 was 85%. It was suggested that HIM82 could enhance the inhibition effect of PT on G-protein. The intracellular [Ca2+] level of Np stimulated with FMLP was decreased by 85%, and that of Np activated with PMA by 100% nearly in the present of HIM82. The activities of PKC and PTK in PMA-stimulated Np were decreased by 23% (P < 0.05) and 35% (P < 0.05) separately when treated with HIM82.The McAb HIM82 could down-regulate the ROS produced from activated Np. The mechanism of decreasing ROS may be involved in down-regulating Ca(2+)-PKC and PTK signal transduction pathway activities that are upstream control systems for NADPH oxidase activation." @default.
- W2390652007 created "2016-06-24" @default.
- W2390652007 creator A5006915742 @default.
- W2390652007 creator A5024419531 @default.
- W2390652007 creator A5073612973 @default.
- W2390652007 date "1999-08-01" @default.
- W2390652007 modified "2023-09-23" @default.
- W2390652007 title "[Down-regulation effect of McAb HIM82 on Ca2+, protein kinase C, protein tyrosine kinase signal pathway of neutrophils]." @default.
- W2390652007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11715414" @default.
- W2390652007 hasPublicationYear "1999" @default.
- W2390652007 type Work @default.
- W2390652007 sameAs 2390652007 @default.
- W2390652007 citedByCount "0" @default.
- W2390652007 crossrefType "journal-article" @default.
- W2390652007 hasAuthorship W2390652007A5006915742 @default.
- W2390652007 hasAuthorship W2390652007A5024419531 @default.
- W2390652007 hasAuthorship W2390652007A5073612973 @default.
- W2390652007 hasConcept C153911025 @default.
- W2390652007 hasConcept C181199279 @default.
- W2390652007 hasConcept C184235292 @default.
- W2390652007 hasConcept C185592680 @default.
- W2390652007 hasConcept C195794163 @default.
- W2390652007 hasConcept C2780795997 @default.
- W2390652007 hasConcept C48349386 @default.
- W2390652007 hasConcept C55493867 @default.
- W2390652007 hasConcept C62478195 @default.
- W2390652007 hasConcept C79879829 @default.
- W2390652007 hasConcept C86803240 @default.
- W2390652007 hasConcept C97029542 @default.
- W2390652007 hasConcept C99971728 @default.
- W2390652007 hasConceptScore W2390652007C153911025 @default.
- W2390652007 hasConceptScore W2390652007C181199279 @default.
- W2390652007 hasConceptScore W2390652007C184235292 @default.
- W2390652007 hasConceptScore W2390652007C185592680 @default.
- W2390652007 hasConceptScore W2390652007C195794163 @default.
- W2390652007 hasConceptScore W2390652007C2780795997 @default.
- W2390652007 hasConceptScore W2390652007C48349386 @default.
- W2390652007 hasConceptScore W2390652007C55493867 @default.
- W2390652007 hasConceptScore W2390652007C62478195 @default.
- W2390652007 hasConceptScore W2390652007C79879829 @default.
- W2390652007 hasConceptScore W2390652007C86803240 @default.
- W2390652007 hasConceptScore W2390652007C97029542 @default.
- W2390652007 hasConceptScore W2390652007C99971728 @default.
- W2390652007 hasIssue "8" @default.
- W2390652007 hasLocation W23906520071 @default.
- W2390652007 hasOpenAccess W2390652007 @default.
- W2390652007 hasPrimaryLocation W23906520071 @default.
- W2390652007 hasRelatedWork W1607877584 @default.
- W2390652007 hasRelatedWork W1978658307 @default.
- W2390652007 hasRelatedWork W2002467106 @default.
- W2390652007 hasRelatedWork W2015677536 @default.
- W2390652007 hasRelatedWork W2053781786 @default.
- W2390652007 hasRelatedWork W2076257864 @default.
- W2390652007 hasRelatedWork W2150291597 @default.
- W2390652007 hasRelatedWork W2390652007 @default.
- W2390652007 hasRelatedWork W2397022935 @default.
- W2390652007 hasRelatedWork W2417616992 @default.
- W2390652007 hasVolume "79" @default.
- W2390652007 isParatext "false" @default.
- W2390652007 isRetracted "false" @default.
- W2390652007 magId "2390652007" @default.
- W2390652007 workType "article" @default.