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- W2390675947 abstract "Objective To study the effect of ototoxicity induced by cisplatin on morphology of haircells and expression of Bcl-2 protein in spiral ganglion cells.Methods The amplitudes of distortion product otoacoustic emission(DPOAE) were measured before all the animals were killed. Left cochleas were taken for cochlear surface preparation to observe haircells in basilar membrane,right cochleas for frozen sections to examine the expressions of Bcl-2 by immunohistochemical method.Results The inner and outer haircells in saline group were kept in integrate structure and regular distribution,swollen haircells and lost cilia were observed in cisplatin group.The amplitudes of DPOAE and expression of Bcl-2 protein in spiral ganglion cells were lower in cisplatin group than in saline group(P0.01).Conclusion Cisplatin caused the morphology damage of inner and outer haircells and downregulated the expression of Bcl-2 protein." @default.
- W2390675947 created "2016-06-24" @default.
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- W2390675947 date "2007-01-01" @default.
- W2390675947 modified "2023-09-26" @default.
- W2390675947 title "Effect of Cisplatin on Morphology and Expression of Bcl-2 Protein in Guinea Pig Cochlea" @default.
- W2390675947 hasPublicationYear "2007" @default.
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