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- W2390680507 abstract "Objective To investigate the relationship of circulating plasminogen activator inhibitor-1 antigen levels and genotype at a single nucleotide insertion/deletion(4G/5G) polymorphism in the promoter region of PAI-1 gene with insulin resistance in T2DM.Methods 156 in-patients with type 2 diabetes as defined by WHO criteria, and 60 normal control were analyzed.4G/5G allele polymorphism in PAI-1 gene promoter region were genetyped by polymerase chain reaction amplification of genomic DNA by using allele specific primers.Meanwhile,blood sugar,GHbAI,fasting insulin,TCH,TG,etc.were measured and the association of PAI-I with insulin resistance was analyzed.Results The frequency of PAI-1 4G/5G genotype showed significant difference between T2DM and normal control group.PAI-1 in 4G/4G genotype was significantly higher than that in the other two genotypes.In three genotypes of T2DM, PAI-1, cholesterol, triglyceride, fasting glucose, fasting insulin, HOMA were significantly higher than that in the corresponding genotypes of normal control group.The correlation between PAI-1 and BMI,TG,fasting insulin,WC,HOMA existed only in 4G/4G genotype.Conclusion This study indicates that in T2DM, PAI-1 level is associated with insulin resistance and genotype in the region of PAI-1 gene promoter.The association between PAI-1 level and both triglyceride and insulin is influenced by genotype in the region of PAI-1 gene promoter." @default.
- W2390680507 created "2016-06-24" @default.
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- W2390680507 date "2005-01-01" @default.
- W2390680507 modified "2023-09-25" @default.
- W2390680507 title "Association of PAI-1 Level and Its Promoter 4G/5G Genotype with Insulin Resistance in T2DM" @default.
- W2390680507 hasPublicationYear "2005" @default.
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