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- W2390683098 abstract "Objective To investigate the effect of tea polyphenol (-) -epigallocatechin gallate (EGCG)on peroxidation-injured neurons acutely exposed to hydrogen peroxide (H2O2). Methods Cortical neurons from embryonic 18 day rats were primarily cultured for 2 days, and divided into 4 groups: ①Normal neuron control group, ②Normal neuron with EGCG group, ③H2O2 -injured neuron group (normal neurons with the treatment of H2O2), and ④EGCG-treatment group (Injured neurons treated with EGCG 30 minutes after H2O2 administration). All the neurons in different groups were cultured for another 36 hours before the morphological changes, viability and malondialdehyde (MDA) production of these neurons were analyzed. Results Most of the neurons in H2O2-injured neuron group exposed to H2O2 were destroyed into debris without complete processes. The neuronal viability decreased significantly with an increased production of MDA. However , cultured neurons in EGCG-treatment group remained an almost normal morphology with a significant increase in the neuronal viability and declined MDA production. Conclusion The outcomes of the present study suggested that EGCG is capable of inhibiting the production of hydroxide radical, thus protecting neurons against peroxidative damage caused by H2O2." @default.
- W2390683098 created "2016-06-24" @default.
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- W2390683098 date "2008-01-01" @default.
- W2390683098 modified "2023-09-23" @default.
- W2390683098 title "Protective effect of tea polyphenol (-)-epigallocatechin gallate on peroxidation-injured neurons acutely exposed to hydrogen peroxide" @default.
- W2390683098 hasPublicationYear "2008" @default.
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