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- W2390692661 abstract "Objective To investigate factors affecting calcium content in aortic valved homograft(AVH) tissues in rats.Methods 90 Wistar rats were randomly allocated into 3 groups: two allogene groups and one isogenenic group.Allogene group: SD→Wistar,one group received AVH of cryopreservation,the other group received AVH pre-conditioned with dendritic cell monoclonal antibodies(DCmAb)diluted by 1:5 and cryo-preserved,and then was treated with DcmAb.Isogenenic group: Wistar→Wistar.AVH with myocardial cuff was heterotopically allografted onto the abdominal aorta of rats.Rats were post-operatively sacrificed in batches at 2,4,8,12 and 16 weeks.Blood samples were obtained for detection of the TCR-α,β and CD28 expressions,and the AVH specimens were obtained for detection of the changes of endotheliocyte and smooth muscle cells with a light and electron microscope,and the CD54 expression by immunohistochemistry.Also,the calcium contents of the AVH tissues after transplantation were determined.Results ① Compared with the isogenic group,the expression of TCR-α,β and CD28 in the allogene group was significantly increased at each time point(P0.01).Compared with the cryopreservation group,the expression of TCR-α,β and CD28 in the DCmAb treatment group was significantly decreased(P0.01).② The calcium contents of AVH tissues in the allogene group gradually increased at 4 weeks,which was significantly different from that in the isogenenic group over 5 different periods(P0.05).In the cryopreservation group,the calcium contents of the AVH tissues were 2 856±79 and 3 587±168 at 4 and 8 weeks postoperatively;were 2176±210,3089±176 in the DCmAb treatment group;and were 860±60,870±50 in the isogenic group.Conclusion Immunosuppressive treatment has obviously effect in lightening the immune rejection response and delaying the AVH calcification course." @default.
- W2390692661 created "2016-06-24" @default.
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- W2390692661 date "2008-01-01" @default.
- W2390692661 modified "2023-09-23" @default.
- W2390692661 title "Quantitative analysis of calcium content in aortic valved homograft tissues in rats" @default.
- W2390692661 hasPublicationYear "2008" @default.
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