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- W2390708880 abstract "Purpose To establish animal models of radiation-induced pulmonary injury by different dose fractionation,and to study the differences of radiation-induced lung injury in different dose fractionation.Methods Using male Wistar rats of SPF level,the right lungs of rats were radiated by 60Co γ-ray.Ninety Wistar rats were randomly divided into Low-dose fraction irradiation group,High-dose fraction irradiation group,and Control group.The TGF-β1 and TNF-α of serum in the 1st,3rd,5th,10th and 24th week after irradiation were measured by ELISA.The histological changes of their right lungs with HE staining from 1st week to 24th week after irradiation were observed.Results High-dose fraction irradiation group,TGF-β1 in serum increased after being radiated,and it reached a peak in 10th week.TGF-β1 in serum remained at high level from 5th week to 24th week.After being radiated,TNF-α in serum increased rapidly from 1st week and reached the peak in 10th week,then declined rapidly.Low-dose fraction irradiation group,TGF-β1,TNF-α in serum increased after irradiation,but the changes were less than that of High-dose fraction irradiation group.The pathological changes in pulmonary tissue had experienced a process from acute radiation-induced pneumonitis to chronic pulmonary fibrosis,including acute inflamma-tion period,hyperplasia period,and fibrosis period.Whether the acute radiation-induced pneumonitis or the radiation-induced pulmonary fibrosis,the Low-dose fraction irradiation group is lighter than the High-dose fraction irradiation group.Conclusion Received the same total doses of irradiation,Low-dose fraction irradiation group has less histological changes and the contents of TGF-β1,TNF-α in serum than High-dose fraction irradiation group,Low-dose fraction irradiation can protect late response tissue." @default.
- W2390708880 created "2016-06-24" @default.
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- W2390708880 date "2012-01-01" @default.
- W2390708880 modified "2023-09-25" @default.
- W2390708880 title "Impact of radiation-induced pulmonary injury in rats by different dose fractionation" @default.
- W2390708880 hasPublicationYear "2012" @default.
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