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- W2390726577 abstract "Objective:To explore the changes and their mechanisms of surfactant protein A and surfactant protein B(SP-A and SP-B ) expression in the lungs of neonatal rats with pulmonary hemorrhage.Methods:Pulmonary hemorrhage model in neonatal rats was established by injecting intraperitoneally at the dosage of 5 mg/kg;and the equal amount of normal saline(NS) was injected intraperitoneally in NS control group.The pathological changes of the lungs were examined at different points of time.Immunohistochemistry,enzyme-labeled immunosorbent assay(ELISA),Western blot and reverse transcription-polymerase chain reaction(RT-PCR) were used to measured the expressions of SP-B,tumor necrosis factor-α(TNF-α),inhibitor of NF-κBα(IκBα) protein and SP-A,SP-B,TNF-α mRNA,respectively.Results:The infiltration of polymorphonuclear neutrophils(PMNs) and the damage of typeⅡ alveolar cells were observed when pulmonary hemorrhage occurred by LPS in neonatal rats.The expressions of SP-B protein and SP-B、SP-A mRNA were lower at 1 h,2 h and 4 h after injecting LPS than the control group,respectively.After the injection of LPS,the expression of lung IκBα at 0.5 h decreased significantly,while the expression of the TNF-α mRNA and protein were significantly higher at 0.5 h and 1 h than the control group,respectively.Conclusion:In pulmonary hemorrhage in neonatal rats caused by LPS,the expressions of SP-B protein and SP-A、SP-B mRNA decreased significantly,which may be related to the degradation of IκBα,the increase of TNF-α,the infiltration of PMNs and the damage of typeⅡ alveolar cells in the lungs." @default.
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- W2390726577 date "2007-01-01" @default.
- W2390726577 modified "2023-09-28" @default.
- W2390726577 title "Changes of SP-A and SP-B expression in the lungs of neonatal rats with pulmonary hemorrhage" @default.
- W2390726577 hasPublicationYear "2007" @default.
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