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- W2390733178 abstract "Objective To investigate the protection and mechanism of Ca 2+ preconditioning by observing the effect of transient ischemic and Ca 2+ preconditioning and PKC activity of mimicking ischemia reperfusion cardiac myocytes.Methods Cultured rat cardiac myocytes were exposed to ischemia (30?min) reperfusion (10 min) mimicking solution after brief ischemic episodes,Ca 2+ and H7 preconditioning.The enzyme activity was determined by measuring the incorperation of γ 32 P ATP into peptide GS.Results Both IPC and CPC could markedly reduce ATP depletion and LDH leakage.The content of ATP was increased by (2.80±0.13) and (2.73±0.19) nmol/g respectively; Leakage of LDH was decreased by (140.10±18.30) and (164.00±17.30) U/L respectively.After Ca 2+ preconditioning the activity of PKC was (77.9±28.5)λ B·pmol -1 ·min -1 ·10 -6 cells,while PKC activity was activated markedly after mimicking ischemia reperfusion (P0.01).CPC exhibited a protective effect similar with IPC.H 7 abolished this preconditioning effect.Conclusion IPC and CPC can induce the same stress cardioprotection,and the signal transduction mediated by PKC plays a crucial role in preconditioning." @default.
- W2390733178 created "2016-06-24" @default.
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- W2390733178 date "2002-01-01" @default.
- W2390733178 modified "2023-09-26" @default.
- W2390733178 title "Protection of Ca~( 2+) preconditioning against mimicking ischemia-reperfusion injury in cultured cardiac myocytes" @default.
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