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- W2390745900 abstract "Objective To investigate the correlations between the expression of multidrug resistance gene 1( MDR1) gene and P- glycoprotein( P- gp) and chemotherapy drug resistance of gastrointestinal( GI) tumor. Methods The expression of MDR1 mRNA and P- gp in 72 patients with GI cancer was measured by RT- PCR and ELISA. The chemotherapy drug sensitivity test was also conducted for correlaion analysis. Results The positive rates of MDR1 and P- gp in GI tumor tissue were 75% and 67%,respectively. There were 12 cases insensitive to 10 chemotherapy drugs; while single- drug,2- drug,3- drug,5- drug,8- drug and all- drug sensitive were revealed in 15,9,9,15,9 and 3 cases,respectively. The positive expression of MDR1 and P- gp was significantly negatively correlated with the sensitivity to chemotherapy in GI cancer( r s =- 0. 672 and- 0. 715,P 0. 05). Conclusion The expression of MDR1 and P- gp is correlated to the drug resistance of GI tumor,which indicates functional linkage of drug resistance." @default.
- W2390745900 created "2016-06-24" @default.
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- W2390745900 date "2013-01-01" @default.
- W2390745900 modified "2023-09-23" @default.
- W2390745900 title "The correlations between the expression of MDR1 gene and P-glycoprotein and chemotherapy drug resistance of gastrointestinal tumor" @default.
- W2390745900 hasPublicationYear "2013" @default.
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