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- W2390747159 abstract "Objective To study the protective effects of antegrade cardioplegia infusion via aortic root and coronary sinus occlusion on the ischemic myocardium. Methods Adult rabbit hearts ( n =18) were infused under the modified Langendorff isolated heart model with 4 cardioplegic infusion rate (2,4,6,8 ml·kg -1 ·min -1 and two degrees of coronary sinus occlusion (CSO, 50% moderate, 85% subtotal occlusion) or without CSO, yielding 12 different combinations. Aortic root infusion pressure (AoP) and coronary sinus pressure (CSP) were measured during each infusion of cardioplegia. Results The cardioplegic infusion rate was markedly related to the AoP ( P 0.01). Occlusion of the coronary sinus changed the normal relationships among infusion rate, AoP and CSP. Each increase of 2 ml·kg -1 ·min -1 in infusion rate from 2 to 8 ml·kg -1 ·min -1 with various degrees of CSO resulted in a significant increase in AoP ( P 0.01). CSO had a positive effect on Aop. Conclusion The induced CSP was safely maintained in the range of 3.3 to 4.7 kPa at the infusion rate of 4 to 6 ml·kg -1 ·min -1 with subtotal CSO." @default.
- W2390747159 created "2016-06-24" @default.
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- W2390747159 date "1999-01-01" @default.
- W2390747159 modified "2023-09-24" @default.
- W2390747159 title "Protective effects of different antegrade infusion rate of cardioplegia with various degrees of coronary sinus occlusion on the ischemic myocardium in the isolated rabbit heart" @default.
- W2390747159 hasPublicationYear "1999" @default.
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