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- W2390756873 abstract "OBJECTIVE: To study the nm23 gene expression changes and its mechanism in the differentiation process of HL-60 cell line by TSA and ICA. METHODS:The changes of proliferation rate and differentiation in HL-60 cells treated with ICA or TSA were observed by MTT test, surface marker analysis and NBT reduction reaction, and the effects on cell cycle and nm23 gene expression by flow cytometry and RT-PCR. RESULTS: After exposing to ICA or TSA, the proliferation was inhibited and the cells were induced to differentiation towards more mature monocytes.The 24, 48 and 72 h restrain rates were (12.73±1.17)%, (38.15±3.32)% and (58.45±3.06)%,respectively. During the differentiation, HL-60 cells were arrested in G1 phase and the expression of nm23 c-myc gene was down regulated, while G-CSF gene was up regulated. CONCLUSION: ICA or TSA could induce differentiation of HL-60 cells, and this effect might be related to the down regulation of nm23 gene expression." @default.
- W2390756873 created "2016-06-24" @default.
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- W2390756873 date "2007-01-01" @default.
- W2390756873 modified "2023-10-04" @default.
- W2390756873 title "Molecular mechanism of trichostatin A facilitating arsenic trioxide to induce HL-60 cells differentiation" @default.
- W2390756873 hasPublicationYear "2007" @default.
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