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- W2390758034 abstract "Objective: To observe the effects of insulin on expression of Aquaporin-9(AQP-9) and brain edema after middle cerebral artery occlusion(MCAO) in rats. Methods: One hundred and eighty SD rats were randomly divided into groups of sham, MCAO and insulin treatment, with 30 rats in each group. Six rats in each group were observed at 6 h, 12 h, 24 h, 48 h, 72 h after MCAO. The MCAO models were estabilish by suture method, and the sham group without suture. The insulin treatment group was given insulin by intraperitoneal injection. The nerve function, blood-brain barrier permeability, brain water content and AQP-9 m RNA expression were evaluated.Results: The brain water content, blood-brain barrier permeability and AQP-9 m RNA expression of groups MCAO and insulin began to increase at 6 h and reached peak at 48 h and gradually decreased at 72 h, which were significantly higher than those in sham group(P0.05). Compared with the MCAO group, the brain water content,blood-brain barrier permeability and AQP-9 m RNA expression in insulin treatment group were obviously decreased(P0.05). There were a significantly passive correlation between AQP-9 m RNA expression and brain water contents, blood-brain barrier permeability(r=0.905, P0.01; r=0.923, P0.01). Conclusion: Insulin can reduce brain edema through suppressing expression of AQP-9 in cerebral ischemia in rats." @default.
- W2390758034 created "2016-06-24" @default.
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- W2390758034 date "2015-01-01" @default.
- W2390758034 modified "2023-09-25" @default.
- W2390758034 title "Effects of Insulin on Expression of Aquaporin-9 and Brain Edema after Focal Cerebral Ischemia in Rats" @default.
- W2390758034 hasPublicationYear "2015" @default.
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