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- W2390762458 abstract "Objective: To explore the clinical correlation of HLA-DRB1 shared epitope with IgA mesangial proliferative glomerulonephritis( IgA Ms PGN). Methods: The renal function were examined routinely,and HLA-DRB1 shared epitope were determined by PCR in a total of 164 patients with IgA Ms PGN and 164 healthy subjects. The renal function and HLA-DRB1 shared epitope were compared in patients with IgA Ms PGN and healthy subjects,and clinical correlation of HLA-DRB1 shared epitope and renal function were analyzed. Results:( 1) 24 h proteinuria,serum creatinine and serum urea nitrogen were significantly different in patients with IgA Ms PGN and healthy subjects( P 0. 01);( 2) The high-frequency gene of HLA-DRB1 in patients with IgA Ms PGN were DRB1 * 04,DRB1* 07,DRB1* 09,DRB1* 11,DRB1* 14 and DRB1* 15;( 3) The distribution frequency of DRB1 * 09 and DRB1 * 11 in patients with IgA Ms PGN increased significantly( P0. 01 or P0. 05);( 4) 24 h proteinuria,serum creatinine and serum urea nitrogen in patients with IgA Ms PGN with DRB1* 09 and DRB1* 11 were significantly different compared with those in patients with IgA Ms PGN with other HLA-DRB1 shared epitope( P 0. 01). Conclusion: HLA-DRB1 shared epitope is related to IgA Ms PGN,DRB1 * 09 and DRB1* 11 can increase the risk of IgA Ms PGN,and related to the severity of glomerulonephritis." @default.
- W2390762458 created "2016-06-24" @default.
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- W2390762458 date "2015-01-01" @default.
- W2390762458 modified "2023-09-23" @default.
- W2390762458 title "Study on HLA-DRB1 shared epitope in patients with IgA mesangial proliferative glomerulonephritis" @default.
- W2390762458 hasPublicationYear "2015" @default.
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