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- W2390769313 abstract "To investigate the polymorphism of FUS2SNP s(767A/T)in non-small cell lung cancer(NSCLC)and explore its clinical significance.METHODS:Totally 84patients with NSCLC were enrolled in our study and another 20 healthy person were as a normal control.The genotypes of FUS2SNP s(767A/T)was performed using the standard Taq-Man assays.RESULTS:The A/A,A/T,and T/T genotypes of FUS2SNP s 767in NSCLC group were accounted for 30.9%,35.7%and 33.3%,respectively;and which in control group were accounted for 20.0%,55.0% and 25.0%,re-spectively.No significant difference of A/A and T/T genotypes was found between NSCLC and control group(P0.05). However,there was significantly difference of A/T genotype between the two groups(35.7%vs 55.0%;χ2=4.62,P 0.05).The C/T genotype was not significant related with gender and smoking(P0.05)but it was significant related with histological grade(47.1%vs 28.0%;χ2=3.89,P0.05),lymphatic metastasis(50.0%vs 25.0%;χ2=4.35,P 0.05),and clinical pathologic stage(45.5% vs 25.0%;χ2=3.66,P0.05)in NSCLC patients(P0.05).CONCLU-SIONS:FUS2SNP s(767A/T)genotype may be a susceptibility genotype in NSCLC.The detection of A/T genotype may be used as a mark for diagnosis in estimating the degree of differentiation or prognosis in NSCLC patients." @default.
- W2390769313 created "2016-06-24" @default.
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- W2390769313 date "2013-01-01" @default.
- W2390769313 modified "2023-09-23" @default.
- W2390769313 title "Polymorphism of FUS2 SNPs in non-small cell lung cancer and its clinical significance" @default.
- W2390769313 hasPublicationYear "2013" @default.
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