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- W2390807288 abstract "Objective To explore the effect of antisense oligodeoxynucleotide(ASODN) of bcl|2 gene on chemotherapy sensitivity and on apoptosis of leukemic cell line U937, which was of bcl|2 overexpression. Methods MTT colorimetric assays was used to detect cytotoxicity. The morphologic signs of apoptosic cells observed by light microscope. The DNA fragment analysed by electrophoresis. The proportion of apotosis cells detected by acridine orange and ethidium bromides(AO/EB) stains. Results There was a significant decrease of survival rate after expose to combintion of bcl|2 ASODN with VP16, compared VP16 alone or combination of sense oligodeoxynucleotide with VP16. After incubation with bcl|2 ASODN, IC-{50}of etoposide on U937 cell line decreased from 4 65 μmol/L to 1 35 μmol/L, ladder|like pattern on agorose gel eletrophoresis indicated bcl|2 ASODN induced U937 cells more sensitive to {etoposide} induced apoptosis. The rate of apoptosis elevated from (19±2 3)% to (32±1 8)%. {Conclusion} bcl|2 ASODN enhances the sensitivity of U937 cell line to etoposide, increase etoposide induced apoptosis. bcl|2 ASODN provide a potential mothod for treatment of hematologic maligancy, especially for overcome chemoresistance." @default.
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- W2390807288 date "2004-01-01" @default.
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- W2390807288 title "Effect of bcl-2 Antisense Oligodeoxynucleotieds on Drug-sensitivity of Leukemic Cell Line U937" @default.
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