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- W2390808670 abstract "Objective To study the immune modulatory mechanisim of the protection of mice against colitis induced by trinitro-benzene-sulfonic acid(TNBS) with Schistosoma japonicum eggs.Methods Mice were immunized 4 times with 10 000 schistosome eggs by intraperitoneal injection with one-week interval.On day 6 after the last immunization the colitis was induced by TNBS and pathologic changes on colon,levels of cytokines and CD4+ CD25+ FoxP3+ T cells of mice were observed and detected in groups of eggimmunized and unimmunized colitis mice.Results In egg-unimmunized colitis mice,after TNBS induction,the inflammation in colon was obvious.And it was characterized with high Th1 cytokine IFN-γ level(3.47±0.87 ng/ml) and lower Th2 cytokine IL-4,IL-5 and IL-10 level(146.06±45.76 pg/ml,140.32±39.01 pg/ml,385.91±134.89 pg/ml,respectively).While in egg-immunized colitis mice,the inflammation was suppressed greatly.And schistosome eggs exposure significantly diminished the expression of IFN-γ(1.53±0.51 ng/ml) and enhanced the production of IL-4,IL-5 and IL-10(598.50±135.90 pg/ml,217.86±77.82 pg/ml,799.651±197.93 pg/ml,respectively) in colitis mice.The proportion of CD4+ CD25+ FoxP3+ T cells in splenocytes was(3.55±0.81)% and higher than that in TNBS-induced colitis mice alone(2.31±0.39)%. Conclusion The eggs of S.japonicum can inhibit the development of colitis induced by TNBS in mice and the modulation of CD4+ CD25+ FoxP3+ T cells to the over-expressed Th1 immune response may be involved in the mechanism." @default.
- W2390808670 created "2016-06-24" @default.
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- W2390808670 date "2007-01-01" @default.
- W2390808670 modified "2023-09-23" @default.
- W2390808670 title "Studies on the mechanism of the protection of Schistosoma japonicum eggs against TNBS-induced colitis in mice" @default.
- W2390808670 hasPublicationYear "2007" @default.
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