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- W2390835626 abstract "Objective To study the effect of estradiol on hematopoietic stem/progenitor cells from patients with systemic lupus erythematosus in vitro .Methods CD34 + cells,CD34 +CD38 - cells,granulocytes,erythrocytes,macrophage megakaryocyte colony formation units (GEMM CFU) and granulocyte macrophage colony formation units (GM CFU) of bone marrow cells from patients with systemic lupus erythematosus (SLE) were assayed respectively by flow cytometer and semi solid methylcellulose culture technique.GM CFU colony formation of bone marrow from patients with SLE was regulated by estradiol alone or in combination with tamoxifen.Results ①The numbers of CD34 + cells,GEMM CFU and GM CFU of bone marrow from SLE were significantly less than those from control.②Estradiol significantly decreased the number of GM CFU colonies from female SLE.③Co treatment with tamoxifen reversed the suppressive action of estrogen.Conclusion Later hematopoietic stem/progenitors of active SLE are abnormal.Estrogen is likely involved in the abnormality of hematopoietic stem/progenitor of active SLE." @default.
- W2390835626 created "2016-06-24" @default.
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- W2390835626 date "2002-01-01" @default.
- W2390835626 modified "2023-09-25" @default.
- W2390835626 title "Effect of estradiol on hematopoietic stem/progenitor cells from patients with systemic lupus erythematosus" @default.
- W2390835626 hasPublicationYear "2002" @default.
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