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- W2390842555 abstract "Objective To evaluate the vascular endothelial function of the old patients with carotid atherosclerosis and the effect of probucol on the vascular endothelial function and the total cholesterol level. Methods Before and after oral administration of probucol,the endothelium-dependent (i.e. flow-mediated dilation,FMD)and endothelium-independent dilation(i.e.nitroglycerin-mediated dilation,NMD)of the 43 old patients with carotid atherosclerosis were detected and compared with 40 old healthy controls.Meanwhile, the plasma level of nitrix oxide(NO) and endothelin(ET) was examined . Results (1)Both FMD and NMD of the brachial artery in the old patients with carotid atherosclerosis were less than those of the controls significantly(P0.05). (2)The plasma concentration of NO of the old patients with carotid atherosclerosis was lower than that of the controls,but the ET level was higher. (3)After 12-week treatment of probucol, the cholesterol level reduced and the vascular endothelial function improved. Conclusions (1)Both FMD and NMD of the old patients with carotid atherosclerosis are impaired. (2) Dysfunction of vascular endothelium exists in the old patients with carotid atherosclerosis.(3)Probucol can decrease the cholesterol level and ameliorate the endothelial function of the old patients with carotid atherosclerosis." @default.
- W2390842555 created "2016-06-24" @default.
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- W2390842555 date "2006-01-01" @default.
- W2390842555 modified "2023-09-24" @default.
- W2390842555 title "Investigation on the vascular endothelial function of the patients with carotid atherosclerosis and on the intervention effect of probucol" @default.
- W2390842555 hasPublicationYear "2006" @default.
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