Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390850801> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2390850801 endingPage "50" @default.
- W2390850801 startingPage "647" @default.
- W2390850801 abstract "To observe the change in sensitivity of vascular smooth muscle to calcium and its role in biphasic vascular reactivity following hemorrhagic shock (HS) in rats.The superior mesenteric artery (SMA) obtained from rats with HS was used to assay the vascular reactivity and sensitivity to calcium by observing the contraction initiated by norepinephrine (NE) and Ca(2+) under depolarizing conditions (120 mmol/L K(+)) with isolated organ perfusion system. At different time points after shock, the relationship between vascular reactivity and sensitivity to calcium was analyzed. Meanwhile the effects of the angiotensin II (Ang II) and insulin, the calcium sensitivity regulating agents, on vascular reactivity were also observed.As compared with the control group, the cumulative dose-response curves of SMA to NE and Ca(2+) at early shock stages, i.e. immediately and 30 minutes after shock, shifted to the left, the maximal contractions (Emax) of NE and Ca(2+) were increased significantly (P<0.05 or P<0.01). But the cumulative dose-response curves of SMA to NE and Ca(2+) at late shock stage shifted to the right, and Emax of NE and Ca(2+) were significantly decreased (P<0.05 or P<0.01). Ang II increased the contractile response of SMA to NE and Ca(2+) when shock persisted for 2 hours, rendering the cumulative dose-response curves of NE and Ca(2+) shifted to the left (P<0.05 or P<0.01). But insulin decreased the contractile response of SMA to NE and Ca(2+) at early stage of shock, rendering the cumulative dose-response curves of NE and Ca(2+) shifted to the right (P<0.05 or P<0.01).Sensitivity of vascular smooth muscle to calcium following hemorrhagic displays a biphasic change. It plays important roles in biphasic vascular reactivity." @default.
- W2390850801 created "2016-06-24" @default.
- W2390850801 creator A5017069269 @default.
- W2390850801 creator A5031335804 @default.
- W2390850801 creator A5055987578 @default.
- W2390850801 creator A5074048271 @default.
- W2390850801 creator A5091020799 @default.
- W2390850801 date "2005-11-01" @default.
- W2390850801 modified "2023-09-23" @default.
- W2390850801 title "[Changes in sensitivity of vascular smooth muscle to calcium and its role in the biphasic change in vascular reactivity following hemorrhagic shock in rats]." @default.
- W2390850801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16297315" @default.
- W2390850801 hasPublicationYear "2005" @default.
- W2390850801 type Work @default.
- W2390850801 sameAs 2390850801 @default.
- W2390850801 citedByCount "0" @default.
- W2390850801 crossrefType "journal-article" @default.
- W2390850801 hasAuthorship W2390850801A5017069269 @default.
- W2390850801 hasAuthorship W2390850801A5031335804 @default.
- W2390850801 hasAuthorship W2390850801A5055987578 @default.
- W2390850801 hasAuthorship W2390850801A5074048271 @default.
- W2390850801 hasAuthorship W2390850801A5091020799 @default.
- W2390850801 hasConcept C126322002 @default.
- W2390850801 hasConcept C134018914 @default.
- W2390850801 hasConcept C146957229 @default.
- W2390850801 hasConcept C163415756 @default.
- W2390850801 hasConcept C2779395532 @default.
- W2390850801 hasConcept C2781300812 @default.
- W2390850801 hasConcept C2992686903 @default.
- W2390850801 hasConcept C519063684 @default.
- W2390850801 hasConcept C71924100 @default.
- W2390850801 hasConceptScore W2390850801C126322002 @default.
- W2390850801 hasConceptScore W2390850801C134018914 @default.
- W2390850801 hasConceptScore W2390850801C146957229 @default.
- W2390850801 hasConceptScore W2390850801C163415756 @default.
- W2390850801 hasConceptScore W2390850801C2779395532 @default.
- W2390850801 hasConceptScore W2390850801C2781300812 @default.
- W2390850801 hasConceptScore W2390850801C2992686903 @default.
- W2390850801 hasConceptScore W2390850801C519063684 @default.
- W2390850801 hasConceptScore W2390850801C71924100 @default.
- W2390850801 hasIssue "11" @default.
- W2390850801 hasLocation W23908508011 @default.
- W2390850801 hasOpenAccess W2390850801 @default.
- W2390850801 hasPrimaryLocation W23908508011 @default.
- W2390850801 hasRelatedWork W2000410859 @default.
- W2390850801 hasRelatedWork W2033659015 @default.
- W2390850801 hasRelatedWork W2051176796 @default.
- W2390850801 hasRelatedWork W2085683781 @default.
- W2390850801 hasRelatedWork W2157447109 @default.
- W2390850801 hasRelatedWork W2207274821 @default.
- W2390850801 hasRelatedWork W2335700637 @default.
- W2390850801 hasRelatedWork W2351502240 @default.
- W2390850801 hasRelatedWork W2356245902 @default.
- W2390850801 hasRelatedWork W2359259526 @default.
- W2390850801 hasRelatedWork W2366551988 @default.
- W2390850801 hasRelatedWork W2369193440 @default.
- W2390850801 hasRelatedWork W2369693141 @default.
- W2390850801 hasRelatedWork W2376795157 @default.
- W2390850801 hasRelatedWork W2383141846 @default.
- W2390850801 hasRelatedWork W2393737621 @default.
- W2390850801 hasRelatedWork W2429003759 @default.
- W2390850801 hasRelatedWork W2622628289 @default.
- W2390850801 hasRelatedWork W3031060277 @default.
- W2390850801 hasRelatedWork W3030034564 @default.
- W2390850801 hasVolume "17" @default.
- W2390850801 isParatext "false" @default.
- W2390850801 isRetracted "false" @default.
- W2390850801 magId "2390850801" @default.
- W2390850801 workType "article" @default.