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- W2390854954 abstract "CDK11p58,a CDK11 /PITSLRE protein kinase family member,is encoded by Cdc2L2,and it plays a crucial role in cell cycle regulation.In order to investigate the relation between CDK11p58 and the proliferation of human pancreatic carcinoma cells,the recombinant eukaryotic expressional plasmid pcDNA3.0-HA-p58 was introduced into human pancreatic ductal adenocarcinoma cell line MIAPaCa-2 by Lipofectamine2000 and the cell was selected by G418.The cell clones which stably overexpress CDK11p58 were identified by Western blot.Cell cycle,cell proliferation and G1 /S related gene mRNA levels were analyzed by flow cytometry assay,MTT assay and real-time PCR assay,respectively.Results showed that the S phase cell proportion,the proliferation activity and the mRNA level of cyclin D1,cyclin D3,p21 gene in pcDNA3.0-HA-p58 transfected cell were significantly increased compare with the cells in vector group and control group(P 0.01).These results indicated that overexpression of CDK11p58 could accelerate MIAPaCa-2 cell G1 /S progression and promote its proliferation." @default.
- W2390854954 created "2016-06-24" @default.
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- W2390854954 date "2010-01-01" @default.
- W2390854954 modified "2023-09-25" @default.
- W2390854954 title "Overexpression of CDK11~(p58) Promotes the Proliferation of Human Pancreatic Ductal Adenocarcinoma Cell MIAPaCa-2" @default.
- W2390854954 hasPublicationYear "2010" @default.
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