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- W2390865710 abstract "Objective:To investigate the mechanism of vascular endothelial growth factor(VEGF) expression in osteoblasts induced by durative pressure.Methods:Osteoblasts were isolated from the calvarias of neonatal(12 days old) Sprague-Dawley rats,cultured and identified according to published protocols.The cells were pretreated with or without PD98059 and cultured for 0.5,2.0,6.0 h under 100 kpa of pressure in sealed containers.The VEGF concentrations secreted into DMEM were detected by ELLSA.The mRNA levels of VEGF were evaluated by RT-PCR.The total ERK1/2 and the phosphorylation of ERK1/2 in osteoblasts were detected by Western blot.Results:The durative pressure increased the expression and secretion of VEGF,and meanwhile the phosphorylation of ERK1/2 in osteoblasts increased significantly.Pretreated the osteoblasts with PD98059 inhibited the phosphoryation of ERK1/2 and reduced the the expression and secretion of VEGF significantly.Conclusion:Durative pressure induces the expression of VEGF in osteoblasts by the activation of ERK1/2." @default.
- W2390865710 created "2016-06-24" @default.
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- W2390865710 date "2011-01-01" @default.
- W2390865710 modified "2023-09-23" @default.
- W2390865710 title "The mechanism of vascular endothelial growth factor expression in osteoblasts induced by durative pressure" @default.
- W2390865710 hasPublicationYear "2011" @default.
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