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- W2390866191 abstract "OBJECTIVE To establish an UFLC/MS/MS method for the determination of disclofenac sodium in human plasma.METHODS The plasma was deproteinated by acetonitrile.The separation was performed on an Ultimate C18(5 mm,2.1 mm×150 mm) column.The mobile phase consisted of acetonitrile-water(45∶55 v/v) containing 2 mmol·L-1 ammonium acetate,was used as the gradient elution.Detection was performed on a tandem mass spectrometry with electrospray ionization source in positive ion mode.Multiple reaction monitoring(MRM) mode with the transition of m/z 295.9→m/z 251.8(disclofenac sodium) and m/z 250.8→m/z 207.9(phenytoin sodium) was used to quantify disclofenac sodium and internal standard respectively.RESULTS The linear range was 1.955-195.5 μg·L-1,and the limit of determination was 1.955 μg·L-1.The method recoveries were 73.92%,80.98%,86.28% respectively and the RSD of intra-day and inter-day was less than 10%.CONCLUSION The method is simple,sensitive,accurate and reproducible.It is applicable for pharmacokinetic study of disclofenac sodium." @default.
- W2390866191 created "2016-06-24" @default.
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- W2390866191 date "2011-01-01" @default.
- W2390866191 modified "2023-09-27" @default.
- W2390866191 title "Determining the content of disclofenac sodium in human plasma by UFLC-MS/MS" @default.
- W2390866191 hasPublicationYear "2011" @default.
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