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- W2390870084 abstract "OBJECTIVE To explore the relation between ApoE gene and traditional Chinese medicinal syndromes of alzheimers so that genomics evidences for the early diagnosis,typing and treatment can be provided.METHOD 131 patients with alzheimers were gathered as experimental group;200 persons including 100 non-zlzheimers patients and 100 healthy people were gathered as control group.Patients in experimental group were typed and classified according to the integrated medicinal standard to exam the ApoE gene's type and diversity.RESULT Five gene types including E2/E3,E4/E2,E4/E3,E3/E3 and E4/E4 were detected.The detection rate of E4(E4/4+E4/E2+E4+E3),E4/E3 and E4/E4 gene types were higher compared with those of control group(P0.05,P0.01).When comparing alzheimers of varied types,E4 gene type in AD had a higher detection rate(P0.05);the detection rate of E4/E4 gene type in AD increased significantly compared with those of VD and non-alzheimers groups(P0.01);the kidney deficiency and blood stasis syndrome in AD group was more than those in the other two groups(P0.05);the detection rate of E4/E4 gene type in kidney deficiency and blood stasis syndrome was higher(P0.05,P0.01).CONCLUSION ApoE4 gene is a susceptible factor for alzheimers,closely related to the occurrence of AD,and its content is proportional to its danger;Kidney deficiency and blood stasis is the main pathogenesis for AD,and E4/E4 gene type is related to kidney deficiency and blood stasis syndrome,which can provide evidence for the early diagnosis,typing and treatment." @default.
- W2390870084 created "2016-06-24" @default.
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- W2390870084 date "2011-01-01" @default.
- W2390870084 modified "2023-09-24" @default.
- W2390870084 title "Relations Between ApoE Genes and Traditional Chinese Medicinal Syndromes of Alzheimers" @default.
- W2390870084 hasPublicationYear "2011" @default.
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