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- W2390880076 abstract "Objective To study the effects of mitomycin C(MMC) of different concentrations and action times on haze and keratocytes in laser-assisted sub-epithelial keratectomy(LASEK).Methods One eye of 40 rabbits was randomly enrolled into the experimental group and treated by LASEK and MMC,the other eye of the 40 rabbits was treated by LASEK only and served as the operation control group.The experimental eyes were randomly divided into four groups and used different concentration MMC by different duration in LASEK: T1 group,0.02% MMC in 10 seconds;T2 group,0.02% MMC in 30 seconds;T3 group,0.08% MMC in 10 seconds;T4 group,0.08% MMC in 30 seconds.Results One week after the operation,the cornea of the T1,T2 and T3 group generally healed but of the T4 group did not healed.Corneal haze formed in all eyes in different degrees,which was more in the operation control group than in the T2,T3 and T4 groups(P0.05),however there was no difference among the T2,T3 and T4 groups(P0.05) and between the T1 and LASEK groups(P0.05).TUNEL cells of keratocytes were obviously different among the four groups,PT4PT3PT2PT1P operation control.Conclusion MMC can decline haze in the LASEK.Increase of concentration and action time will significantly inhibit the formation of haze and increase the apoptosis of keratocytes.In this study,0.08% MMC acting 30 seconds did the best in effect,but it resulted in damage of the cornea and long repair of the epithelium." @default.
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- W2390880076 date "2012-01-01" @default.
- W2390880076 modified "2023-09-24" @default.
- W2390880076 title "Influence of Mitomycin C in formation of haze and keratocyte after LASEK" @default.
- W2390880076 hasPublicationYear "2012" @default.
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