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- W2390889655 abstract "The melanogenic actions are mediated by the melanocortin-1 receptor(MC1R). MC1R is a member of the G-protein-coupled receptor(GPCR) superfamily expressed in cutaneous and hair follicle melanocytes. Activation of MC1R by adrenocorticotrophin or α-melanocyte stimulating hormone is positively coupled to the cAMP signaling pathway and leads to a stimulation of melanogenesis and a switch from the synthesis of pheomelanins to the production of eumelanic pigments. The functional behavior of the MC1R agrees with emerging concepts in GPCR signaling including dimerization,coupling to more than one signaling pathway. In addition,MC1R displays unique properties such as an unusually high number of natural variants often associated with clearly visible phenotypes. Therefore MC1R is an ideal model to study GPCR function. Here the structure and function of MC1R were reviewed." @default.
- W2390889655 created "2016-06-24" @default.
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- W2390889655 date "2008-01-01" @default.
- W2390889655 modified "2023-09-28" @default.
- W2390889655 title "Structure and Function of Melanocortin-1 Receptor" @default.
- W2390889655 hasPublicationYear "2008" @default.
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