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- W2390894611 abstract "Objective: To study on the anti-tumor effect and mechanism of sinapine on mice with H22 hepatocellular carcinoma. Methods: The ascitic type and solid tumor of H22 were established to observe the anti-tumor effect of sinapine. HE staining was used to observe the cellular morphology. The thymus index and spleen index were used to analyze the inl uence of sinapine on the immune organs. Apoptosis morphology of cells was observed by using acridine orange(OA) stain. Agarose gel electrophoresis(AGE) and immunohistochemical were used to study the apoptosis mechanism induced by sinapine. Results: The solid tumor inhibition ratio of high, middle and low dose of sinapine treated groups were 40.3%, 28.4% and 20.8% respectively, but there was no signii cant effect of the inl uence of sinapine on the life extension of H22 ascites type mice. Sinapine could promote the expression of Bax(P0.01) and control the expression of Bcl-2(P0.01). Conclusion: Sinapine could inhibit the H22 solid tumor on mice signii cantly with dose-dependent and no obvious side effect. The probable route of inhibitory effect of sinapine on mice with H22 solid tumor is immune-enhancement and acceleration of cell apoptosis." @default.
- W2390894611 created "2016-06-24" @default.
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- W2390894611 date "2014-01-01" @default.
- W2390894611 modified "2023-09-24" @default.
- W2390894611 title "Preliminary study on anti-tumor effect of sinapine on mice with H22 hepatocellular carcinoma" @default.
- W2390894611 hasPublicationYear "2014" @default.
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