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- W2390896174 abstract "Objective To prepare high titer antiserum against measles virus and use for the virus identification,mycoplasma examination in control tests on vaccine as well as combined titration test on MM and MMR vaccines.Methods Measles virus L4 strain was subcultured in Vero cells to obtain high titer virus bulk and prepare the antigen for immunization.Rabbits were injected with the prepared antigen by i.p.,i.v.and s.c.routes respectively,and the obtained antisera were subjected to control tests according to the requirements in Chinese Pharmacopoeia.Results The neutralizing titers of antisera prepared by immunization of rabbits by i.p.,i.v.and s.c.routes were 1 ∶ 960,1 ∶ 2 560 and 1 ∶ 3 840 respectively.All the antisera met the requirements for control tests on vaccine.Conclusion The preparation of antiserum against measles virus by s.c.injection in several sites on back of rabbits was simple,and the prepared serum reached the highest titer,which might be an optimal method for preparation of high titer antiserum against measles virus." @default.
- W2390896174 created "2016-06-24" @default.
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- W2390896174 date "2011-01-01" @default.
- W2390896174 modified "2023-09-22" @default.
- W2390896174 title "Preparation and Quality Control of High Titer Antiserum against Measles Virus" @default.
- W2390896174 hasPublicationYear "2011" @default.
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