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- W2390908666 abstract "Objective To investigate the relationship between the complexity of HCV 1b NS5A genes and therapeutic response to interferon alpha (IFN α). Methods All of the 13 patients studied were infected with HCV 1b and treated with IFN α, but therapeutic response to IFN α were different. HCV RNA was extracted from pretreatment serum and HCV NS5A gene was amplified by reverse transcription nested PCR. The PCR products were connected to T vector after purification, and cloning. Thirty positive clones were randomly selected to amplify again with PCR. Clonotypes were determined by single strand assay ( single stranded conformational polymorphism, SSCP) and double strand assay (heteroduplex analysis, HD) on the same gel by polyacrylamide electrophoresis (PAGE). The number of clonotypes represented the complexity of HCV NS5A genes. Results The group with complete response, partial response and non response had 6.3 clonotypes, 8.6 clonotypes and 15.8 clonotypes respectively on average. Conclusions There exists a negative correlation between the HCV NS5A gene complexity and the therapeutic efficacy of IFN α." @default.
- W2390908666 created "2016-06-24" @default.
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- W2390908666 date "2002-01-01" @default.
- W2390908666 modified "2023-09-28" @default.
- W2390908666 title "Relationship between the complexity of HCV-1b NS5A genes and the therapeutic response to interferon-α" @default.
- W2390908666 hasPublicationYear "2002" @default.
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