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- W2390910569 abstract "Objective To explore the change of endogenous activin A(ACT A) level,and the relationship of serum ACT A level with the occurrence,severity,and prognosis of hypoxic-ischemic encephalopathy(HIE) in asphyxi-ated neonates.Methods The levels of serum ACT A,FGF and TNF-α at postnatal day 1(P1)(umbilical cord blood) and day 7(P7)(peripheral blood) were measured by enzyme-linked immunosorbent assay(ELISA) in 58 asphyxiated term neonates and 30 normal control neonates.The clinical manifestations were recoroled including consciousness,muscle tone,primitive reflexes,seizure,changes of the pupils,breathing,heart rate,and tension of the fontanel.Diagnosis and grading of HIE were performed according to both the clinical manifestations and the findings of cranial CT scan.Results The levels of ACT A(3.64 ± 0.69 ng /ml vs 2.95 ± 0.34 ng /ml,P 0.01),FGF(77.55 ± 23.18 pg /ml vs 36.43 ± 9.51 pg /ml,P 0.01) and TNF-α(10.72 ± 1.50 ng /ml vs 9.15 ± 0.99 ng /ml,P 0.01) were much higher in asphyxiated neonates at P1 compared with those in control neonates.There was a negative correlation between the level of serum ACT A and Apgar score at 1 minute after birth(r =-0.948,P 0.01).The levels of ACT A(5.59 ± 1.33 ng /ml vs 2.93 ± 0.25 ng /ml,P 0.01) and FGF(64.21 ± 18.70 pg /ml vs 41.69 ± 9.08 pg /ml,P 0.01) were still higher in asphyxiated neonates at P7 than those in control neonates,while no significant difference in the level of TNF-α was found between asphyxiated neonates and control neonates(9.41 ± 0.87 ng /ml vs 9.03 ± 1.06 ng /ml,P 0.05).The clinical manifestations were scored in asphyxiated neonates according to the grading of HIE.The statistic analysis showed a positive correlation between the level of the serum ACT A and severity of HIE(r = 0.962,P 0.01).Conclusions Endogenous ACT A was probably involved in the pathogenesis of HIE.The profile of serum ACT A level may be important in evaluating the severity and prognosis of HIE in asphyxiated neonates." @default.
- W2390910569 created "2016-06-24" @default.
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- W2390910569 date "2009-01-01" @default.
- W2390910569 modified "2023-09-24" @default.
- W2390910569 title "Association of activin A with hypoxic-ischemic encephalopathy in asphyxiated neonates" @default.
- W2390910569 hasPublicationYear "2009" @default.
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