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- W2390915238 abstract "Aim To examine neuroprotection induced by PAE and its molecular mechanisms.Methods In rat middle cerebral artery occlusion(MCAO) and reperfusion model,PAE(2.5,5.0,10 mg·kg-1,i.p.,14 days) significantly reduced the infarct volume and reversed neurological deficits caused by ischemia.Further investigation was carried out through examining the effects of PAE on muscarinic receptor signaling pathways including muscarinic receptors,G proteins and ATP-sensitive potassium channel(KATP).Results PAE markedly increase the M1-type muscarinic receptor related signaling activation,however,it inhibited M2-type muscarinic receptor related signaling activation.Second,PAE increased Kir6.2/Kir6.1 ratio by activating KATP channels.The above effects of PAE all contributed to its neuroprotection.Conclusion Neuroprotection induced by PAE is targeting muscarinic receptor signaling pathways." @default.
- W2390915238 created "2016-06-24" @default.
- W2390915238 creator A5039053532 @default.
- W2390915238 date "2012-01-01" @default.
- W2390915238 modified "2023-09-25" @default.
- W2390915238 title "Neuroprotection induced by paeoniflorin against cerebral ischemiathrough mediating muscarinic receptor signaling pathway" @default.
- W2390915238 hasPublicationYear "2012" @default.
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