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- W2390919368 abstract "Background Adrenomedullin 2(AM2) is a new member of the calcitonin/calcitonin gene-related peptide superfamily.This family includes calcitonin gene-related peptide(CGRP),adrenomedullin(ADM) calcitonin and amylin.Many researches indicated AM2 plays an important role in the cardiac pathology.Objective To observe the cardiovascular effects of AM2 on SHR and possible mechanism with exogenous administration AM2 in vivo.Methods Twenty-four 11-weeks-old male SHR were randomly divided into control group(n=8),ADM group(n=8) and AM2 group(n=8).The administration of AM2 was via mini-osmotic pumps which were inserted s.c.into the dorsum of rats.The osmotic pumps were filled with saline alone,saline containing of AM2 [500 ng/(kg·h)] or ADM [500(ng/(kg·h)].Blood pressure and heart function were evaluated by a right cardiac catheterization at Day 14.With the method of semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR),mRNA expression of atrial natriuretic peptide(ANP) and brain natriuretic peptide(BNP) were determined by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR).Results 1)Compared with that in SHR control group,SBP,±LV dp/dtmax,and LVSP were decreased significantly(P0.01) in AM2 group.2)The levels of ANP and BNP mRNA in cardiac muscle were higher in AM2 group compared with that in SHR control groups(P0.01).Conclusion AM2 decreases SHR blood pressure significantly and improves heart function.In addition to the previously reported mechanism by which AM2 regulates the body's levels of cAMP and NO,AM2 may decrease BP and heart protection via regulation of ANP and BNP level in myocardium." @default.
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- W2390919368 date "2007-01-01" @default.
- W2390919368 modified "2023-09-23" @default.
- W2390919368 title "Effect of Adrenomedullin 2 on Blood Pressure and Heart Function in SHR" @default.
- W2390919368 hasPublicationYear "2007" @default.
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