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- W2390924306 abstract "Objective To explore the relevance of serum tumor necrosis factor alpha(TNF-α),soluble tumor necrosis factor receptor Ⅱ(sTNFR Ⅱ) and soluble intercellular adhesion molecule(sICAM-1) in Graves ophthalmopathy(GO) patients with hyperthyroidism after 131I treatment.Methods The patients for 131I treatment 6 to 12 months were divided into three groups: with no eye symptoms(no GO group) in 14,mild(mild GO group) in 35 and moderate GO(moderate GO group) in 35.Ophthalmopathy was also scored based on the NOSPECS classification.The activity of GO was assessed by means of a numerical clinical activity score(CAS),and divided into activity group in 32 and static group in 38.Serum TNF-α,sTNFR Ⅱ and sICAM-1 level were detected by ELISA.Results Serum sICAM-1 level of activity group(1211.9±258.6 ng/ml) was significantly higher than those in the control group(697.8 ± 291.0 ng/ml),no GO group(797.6±250.0 ng/ml) and static group(807.9±330.2 ng/ml,P0.01).Serum TNF–α levels of static group and activity group(378.1±167.9 ng/L,391.6±150.7 ng/L) were higher than no GO group and control group(P0.01).Serum sTNFRⅡ levels of no GO group(730.0±173.3 ng/ L),static group(1055.1±422.9 ng/ L) and activity group(960.0±435.4 ng/ L) were higher than those of control group(P0.01).Serum TNF-α levels of static group and activity group(378.1±167.9 ng/L,391.6±150.7 ng/L) were higher than no GO group and control group(P0.01).Serum sICAM-1 and TNF-α levels of mild GO and moderate GO groups(1032.4±232.3 ng/ml,407.0±158.1 ng/L and 1021.9±448.9 ng/ml,375.2±157.8 ng/L) were higher than those in no GO group and control group(P0.05).And serum sTNFRⅡ levels of no GO group,mild GO group and moderate GO group(730.0±173.3 ng/ml,1154.4± 422.9 ng/L,922.1±440.6 ng/L) were higher than those in the control group(P0.05).There were positive correlation between sICAM-1 and TNF-α,sICAM-1 and sTNFRⅡ(r= 0.377,P=0.001,r=0.434,P = 0.001),TNF-α and sTNFRⅡ(r=0.476,P0.001)in all GD patients.Conclusion In early period of 131I treatment,we might evaluate comprehensively activity exorbitism,the inflammatory and immune response,fibrous tissue change within orbit and hyperthyroidism relieve through the expression in serum sICAM-1,TNF-α and sTNFR Ⅱ,and if combined CAS,might to understand immunology and apoptosis state of the prognosis GO patients,guiding therapy of GO." @default.
- W2390924306 created "2016-06-24" @default.
- W2390924306 creator A5052107861 @default.
- W2390924306 date "2011-01-01" @default.
- W2390924306 modified "2023-09-26" @default.
- W2390924306 title "Study in serum TNF-α,sTNFRII and sICAM-1 of Graves' ophthalmopathy after ~(131)I treatment" @default.
- W2390924306 hasPublicationYear "2011" @default.
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