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- W2390937384 abstract "Objective To study the protection effects of lactobacillus Streptococcus thermophilus grx02 on the mitochodria of alcoholic liver injury in rats and explore its possible protection mechanism.Method Seventy Wistar rats were randomly divided into seven groups:control group,model group,Dongbao Gantai group,grx02 fermented milk groups(high,middle,low-dose) and positive control group.The control group and model group were gavaged with distilled water 14 ml/kg for 6 w.The Dongbao Gantai group,grx02 fermented milk groups were gavaged with 14 ml/kg of Dongbao Gantai,108,107,106 cfu/ml fermented milk for 6 w respectively.The positive control group was gavaged with 108 cfu/ml fermented milk 14 ml/kg.At the end of experiment,all groups except the conrol group were admimistend 14 ml/kg 50% ethanol at 1 hr after last gavage,while the control group was shill given 14 ml/kg distilled water.Then all rats were fasted for 12 h and then sacrificed.The serum levels of glutamate aminotransferase(ALT),aspartate aminotransferase(AST),and triglycerides(TG) were measured,while mitochondria malondialdehyde(MDA),the activity of superoxide dismutase(SOD),Na+-K+-ATPase,Ca2+-ATPase of extracted mitochodria were also determined.Results Compared with the model group,Streptococcus thermophilus grx02 could decrease the serum levels of ALT,AST,TG,and increase the activity of Na+-K+-ATPase,Ca2+-ATPase in mitochodria(P0.05).Meanwhile,the indices of high-dose group were more potent than those of other groups.Conclusion Streptococcus thermophilus grx02 could improve the function of alcohol-induced liver injury,obviously suppress the action of lipid peroxidation of mitochodria induced by alcohol and enhance the activities of Na+-K+-ATPase, Ca2+-ATPase.Streptococcus thermophilus grx02 has remarkable protective effect on alcohol-induced liver injury by increasing the activity of ATP-dependent enzyme in mitochodria and reducing the injury." @default.
- W2390937384 created "2016-06-24" @default.
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- W2390937384 date "2012-01-01" @default.
- W2390937384 modified "2023-09-25" @default.
- W2390937384 title "THE PROTECTIVE EFFECTS OF STREPTOCOCCUS THERMOPHILUS grx02 FERMENTED MILK ON ALCOHOLIC LIVER INJURY IN RATS" @default.
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