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- W2390941193 abstract "Objective:To investigate the effects of volatile oil of Nardostachy chinesis Batal (VONCB) on current of Nav1.5 channels in human embryonic kidney (HEK) cells. Methods: VONCB extracted from chinese medicine Nardostachy Chinesis Batal as testing drug. Nav1.5 channels from cDNA on encoding mouse with the composition of pure sodium channels expression in HEK cells. The whole-cell patch clamp recording procedures and methods was employed.Results: The results of this study was found that the effects of block of Na current depended on different concentrations of VONCB and the impact of the lower membrane potential (the potential shift up), the stronger block. the volume-effect response was S curve type. Conclusion: The VONCB has potential role of significant block of sodium current, and this role is increased with the dosage increased and the action strengthening with the membrane potential lowing. The results suggest that the arrhythmia induced by myocardial ischemia can be treated by VONCB." @default.
- W2390941193 created "2016-06-24" @default.
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- W2390941193 date "2009-01-01" @default.
- W2390941193 modified "2023-09-27" @default.
- W2390941193 title "Blockade of current of Nav1.5 in HEK cells depended by the voltage and concentration of volatile oil of Nardostachy Chinesis Batal" @default.
- W2390941193 hasPublicationYear "2009" @default.
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