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- W2390943956 abstract "Objective: To observe the improvement of liver function by using low-dose EP regimen(etoposide and cisplatin) in small cell lung cancer patients with hepatic metastasis and severe liver dysfunction. Methods: From 2007 to 2012,chemotherapy-naive patients who had small cell lung cancer with severe liver dysfunction(aspartate aminotransferase and/or alanine aminotransferase ≥ 5×ULN, total bilirubin ≥ 3×ULN before chemotherapy) secondary to hepatic metastasis were recruited, and treated with low-dose EP regimen which was intravenous infusion of etoposide 100 mg and cisplatin 20 mg from day 1 to 5 with every 3 weeks as a cycle. Liver function indexes were tested after two cycles of chemotherapy. Results: All those patients' liver function improved after chemotherapy. Conclusion: After the exclusion of other liver diseases, low-dose EP regimen was relatively safe in the small cell lung cancer patients with hepatic metastasis and severe liver dysfunction, and could improve the patients' liver function. The further study should be warranted to confirm the clinical effect." @default.
- W2390943956 created "2016-06-24" @default.
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- W2390943956 date "2013-01-01" @default.
- W2390943956 modified "2023-09-23" @default.
- W2390943956 title "Efficacy observation of low-dose EP regimen in the treatment of small cell lung cancer patients with hepatic metastasis and severe liver dysfunction" @default.
- W2390943956 hasPublicationYear "2013" @default.
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