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- W2390947014 abstract "Objective To investigate the relationships between the expression of VEGF,its receptor KDR/flk-1,cNOS mRNA and angiogenesis,cell proliferation,metastasis in human hepatocellular carcinoma(HCC). Methods Immunohistochemical analysis using antibodies against VEGF and its kinase insert domain receptor (KDR) was carried out.cNOS mRNA expression in HCC,liver cirrhosis and normal liver tissue was observed by in situ hybridization.CD34 immunostaining was used to measure the microvascular density(MVD)and proliferative index was evaluated by Ki-67 immunostaining. Results The expressions of VEGF and KDR of HCC were significantly related to MVD,proliferation and metastasis of HCC(P0.01,0.05,0.01,respectively).A significant positive relationship between the expression of cNOS mRNA in endothelial cells and the expression of VEGF in tumor cells was observed(Pearson=0.2984,P0.05).The MVD in HCC with positive expression of both cNOS mRNA and VEGF was the highest,but cNOS mRNA had no effect on MVD in HCC where the VEGF was negative.Conclusion The result suggested that the expession of VEGF in HCC was significantly related to angiogenesis,cell proliferation and metastasis of HCC,and cNOS might be involved in VEGF signaling required for angiogenesis of HCC." @default.
- W2390947014 created "2016-06-24" @default.
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- W2390947014 date "2005-01-01" @default.
- W2390947014 modified "2023-09-25" @default.
- W2390947014 title "RELATIONSHIPS BETWEEN EXPRESSION OF VEGF, cNOS AND ANGIOGENESIS,CELL PROLIFERATION IN HUMAN HEPATOCELLULAR CARCINOMA" @default.
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